Professor Veronica van Heyningen: Medical and Developmental Genetics

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Genes, Environment and Evolution in Eye Development
and Malformations: PAX6, SOX2, OTX2


Collaborations and Laboratory Members

 

Many other clinicians with regular interactions in the UK: London, Oxford, Cambridge, Birmingham, Newcastle, Belfast and Dublin, and worldwide: Germany, Belgium, Portugal, the Netherlands, Scandinavia, Canada, Australia, South Africa, USA. The clinical collaborators are critical and we have ongoing dialogues on phenotype discovery, broadening and evolution.

 

Lab Members

Current lab members involved in this work are:

  • Dr Dirk-Jan Kleinjan PhD
    Senior Investigator Scientist
  • Dr Patricia Yeyati PhD
    Senior Investigator Scientist
  • Dr Pedro Countino PhD
    Marie Curie Postdoctoral Fellow
  • Dr Kathy Williamson PhD
    Senior Research Associate (3/5)
  • Dr Alison Brown PhD
    Senior Research Associate (2/5)
  • Anne Seawright HND
    Senior Research Assistant
  • Keith Erskine
    Technician
  • SM Sharifuzzaman
    Fish Facility Manager
  • Angela Ludwig
    Personal Assistant

Close collaboration with

  • Dr Pedro Countino PhD
    Investigator Scientist in Biomedical Systems Analysis Section

Current grants in addition to MRC core funding

  • EU FP6: Evigenoret (ending April 2009)
  • NIH RO1 collaboration with Dr Rob Grainger from January 2009
  • EU FP7: NeuroXsys – starting July 2009

 

Our work is currently focused on three key areas

  1. Genetics of developmental eye malformations
  2. How gene expression is regulated
  3. How stress response pathways modulate the effect of mutations

 

Collaborations within IGMM

The groups of:

Outwith the Institute

  • David Price (PAX6 and related genes in development, University of Edinburgh)
  • Sanjay Sisodiya et al and Doris Bamiou (Brain MRI and audiology, Institute of Neurology, UCL)
  • John Crolla et al (PAX6 deletion and mutation studies WAGR and, Wessex Regional Genetics Laboratory)
  • Madan Babu (Bioinformatics, MRC LMB, Cambridge)
  • Peri Tate (Mouse models, Sanger Institute, Hinxton, Cambridge)
  • Rob Grainger (Xenopus tropicalis model for eye development, University of Virginia, Charlottesville, USA)
  • Thomas Becker (Long Range control, Bergen, Norway and Sydney, Australia)
  • Hisato Kondoh et al (SOX2-PAX6 interactions, Osaka, Japan)
  • Susan Lindsay (PAX6 expression in developing humans, Institute of Human Genetics, Newcastle)
  • Graeme Black et al (Genetic mechanisms, Manchester)
  • Pascal Dolle (Developmental genes in the adult eye, tissue expression studies, Strasbourg, France - EU IP)
  • Sandro Banfi and Brunella Franco (Developmental genes in adult eye and in MAC anomalies, Naples, Italy - EU IP)
  • Kerstin Kutsche (Clinical Genetics Department, Hamburg, Germany) Clinicians providing patients and insights
  • Tony Moore (Ophthalmologist, Moorfields Eye Hospital, London)
  • Birgit Lorenz, Markus Preising (Ophthalmologist, Giessen, Germany)
  • Francoise Meire (Ophthalmologist, Brussels and Ghent, Belgium)