Research Biographies

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PROFESSOR RICHARD BALDOCK

Biomedical Systems Analysis

Head of Biomedical Systems Analysis


Richard Baldock

Contact Details

E-mail address: richard.baldock@hgu.mrc.ac.uk
Telephone: +44 (0)131 467 8434
Fax: +44 (0)131 467 8456
Address: Medical Research Council
Human Genetics Unit
Western General Hospital
Crewe Road
Edinburgh EH4 2XU
Research Programme: EMAP: e-Mouse Atlas Project

 

 

Research Areas

My background is in theoretical physics and my research in the Human Genetics Unit is directed to understanding the genetic control of development. In collaboration with Dr Duncan Davidson I have developed the atlas-based concept for spatio-temporal databases in biomedicine and in particular the Edinburgh Mouse Atlas and associated databases (www.e-mouseatlas.org). In this context my research interests span image processing for 3D model reconstruction, spatio-temporal data-mapping, in situ gene-expression pattern analysis, bioinformatics, atlas-based biomedical databases, high throughput data capture and analysis, data/database interoperability and e-science.

 

The Mouse Atlas programme has a pivotal role in the delivery of embryo gene-expression resources internationally with direct involvement in special systems databases (www.gudmap.org, www.euregene.org), high throughput data capture (www.eurexpress.org), human embryo (www.ncl.ac.uk/ihg/EADHB, www.dgemap.org) and most recently a chick embryo atlas.

 

Recent Publications

  • Richardson, L.; Venkataraman, S.; Stevenson, P.; Yang, Y.; Burton, N.; Rao, J.; Fisher, M.; Baldock, R.A.; Davidson, D.R. and Christiansen, J.H. EMAGE mouse embryo spatial gene expression database: 2010 update. Nucleic Acids Res 38(Database issue): D703-D709, 2010 PubMed Abstract
  • Wang, X.; Lindsay, S. and Baldock, R. From spatial-data to 3D models of the developing human brain. Methods 50:96-104, 2010
  • Delaurier, A.; Burton, N.; Bennett, M.; Baldock, R.; Davidson, D.; Mohun, T.J. and Logan, M.P. The Mouse Limb Anatomy Atlas: an interactive 3D tool for studying embryonic limb patterning.
    BMC Dev Biol 8:83, 2008 Pubmed Abstract
  • Fisher, M.E.; Clelland, A.K.; Bain, A.; Baldock, R.A.; Murphy, P.; Downie, H.; Tickle, C.; Davidson, D.R. and Buckland, R.A. Integrating technologies for comparing 3D gene expression domains in the developing chick limb. Developmental Biology 317(1):13-23, 2008 PubMed Abstract
  • van Hemert, J.I. and Baldock, R.A. Matching Spatial Regions with Combinations of Interacting Gene Expression Patterns. Communications in Computer and Information Science 13:347–361, 2008
  • Little, M.H.; Brennan, J.; Georgas, K.; Davies, J.A.; Davidson, D.R.; Baldock, R.A.; Beverdam, A.; Bertram, J.F.; Capel, B.; Chiu, H.S.; Clements, D.; Cullen-McEwen, L.; Fleming, J.; Gilbert, T.; Herzlinger, D.; Houghton, D.; Kaufman, M.H.; Kleymenova, E.; Koopman, P.A.; Lewis, A.G.; McMahon, A.P.; Mendelsohn, C.L.; Mitchell, E.K.; Rumballe, B.A.; Sweeney, D.E.; Valerius, M.T.; Yamada, G.; Yang, Y. and Yu, J. A high-resolution anatomical ontology of the developing murine genitourinary tract. Gene Expr Patterns 7(6):680-699, 2007 PubMed Abstract
  • van Hemert, J. and Baldock, R. Mining Spatial Gene Expression Data for Association Rules.
    Lecture Notes in Computer Science 4414:66-76, 2007.
  • Christiansen, J.H.; Yang, Y.; Venkataraman, S.; Richardson, L.; Stevenson, P.; Burton, N.; Baldock, R.A. and Davidson, D.R. EMAGE: a spatial database of gene expression patterns during mouse embryo development. Nucleic Acids Res 34(Database issue):D637-D641, 2006
    PubMed Abstract
  • Baldock, R. and Burger, A. Anatomical ontologies: names and places in biology. Genome Biology 6(4):108, 2005 PubMed Abstract

Book

  • Burger, A.; Davidson, D. and Baldock, R.A. (eds.) Anatomy Ontologies for Bioinformatics: Principles and Practice. Springer, 2008

Book Chapters

  • Christiansen, J.H.; Davidson, D. and Baldock, R.A. Management of Spatially Organized Biological Data using EMAGE. In: Bioinformatics for Systems Biology. Krawetz, S. (Ed.) Humana Press, New York, 2nd edition, 461-476, 2009

  • Baldock, R. A. and Davidson, D. The Edinburgh Mouse Atlas. In: Anatomy Ontologies for Bioinformatics: Principles and Practice. Burger, A.; Davidson, D. and Baldock, R. (eds.) 249-265, 2008

  • Baldock, R. A. and Burger, A. Anatomical Ontologies: Linking Names to Places in Biology. In: Anatomy Ontologies for Bioinformatics: Principles and Practice. Burger, A.; Davidson, D. and Baldock, R.A. (eds.) 197-211, 2008