Research Biographies

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PROFESSOR NICHOLAS HASTIE, CBE FRS FRSE

Medical and Developmental Genetics

Director of the MRC Human Genetics Unit

Director of the Institute of Genetics and Molecular Medicine (IGMM)


Nicholas Hastie

Contact Details

E-mail address: n.hastie@hgu.mrc.ac.uk
Telephone: +44 (0)131 332 2471
Fax: +44 (0)131 467 8456
Address: Medical Research Council
Human Genetics Unit
Western General Hospital
Crewe Road
Edinburgh EH4 2XU
Research Programme: Cancer, Development and Adult Tissue Maintenance

 

Key/Selected Publications

  • Chau YY, Brownstein D, Mjoseng H, Lee WC, Buza-Vidas N, Nerlov C, Jacobsen SE, Perry P, Berry R, Thornburn A, Sexton D, Morton N, Hohenstein P, Freyer E, Samuel K, Van't Hof R, Hastie N: Acute multiple organ failure in adult mice deleted for the developmental regulator wt1
    PLoS Genet 7:e1002404, 2011.
    PubMed Abstract
  • Essafi A, Webb A, Berry RL, Slight J, Burn SF, Spraggon L, Velecela V, Martinez-Estrada OM, Wiltshire JH, Roberts SG, Brownstein D, Davies JA, Hastie ND, Hohenstein P: A Wt1-Controlled Chromatin Switching Mechanism Underpins Tissue-Specific Wnt4 Activation and Repression
    Dev Cell 2011
    PubMed Abstract
  • Guadix JA, Ruiz-Villalba A, Lettice L, Velecela V, Munoz-Chapuli R, Hastie ND, Perez-Pomares JM, Martinez-Estrada OM: Wt1 controls retinoic acid signalling in embryonic epicardium through transcriptional activation of Raldh2. Development 138:1093-1097, 2011.
    PubMed Abstract
  • Dudnakova, T.; Spraggon, L.; Slight, J. and Hastie, N. Actin: a novel interaction partner of WT1 influencing its cell dynamic properties. Oncogene 29(7):1085-92, 2010
    PubMed Abstract
  • Martinez-Estrada, O.M.; Lettice, L.A.; Essafi, A.; Guadix, J.A.; Slight, J.; Velecela, V.; Hall, E.; Reichmann, J.; Devenney, P.S.; Hohenstein, P.; Hosen, N.; Hill, R.E.; Munoz-Chapuli, R. and Hastie, N.D. Wt1 is required for cardiovascular progenitor cell formation through transcriptional control of Snail and E-cadherin Nat.Genet. 42(1):89-93, 2010
    PubMed Abstract

 

Recent Publications

  • Veikkolainen V, Naillat F, Railo A, Chi L, Manninen A, Hohenstein P, Hastie N, Vainio S, Elenius K: ErbB4 Modulates Tubular Cell Polarity and Lumen Diameter during Kidney Development. J Am Soc Nephrol 2011. PubMed Abstract
  • Huffman JE, Knezevic A, Vitart V, Kattla J, Adamczyk B, Novokmet M, Igl W, Pucic M, Zgaga L, Johannson A, Redzic I, Gornik O, Zemunik T, Polasek O, Kolcic I, Pehlic M, Koeleman CA, Campbell S, Wild SH, Hastie ND, Campbell H, Gyllensten U, Wuhrer M, Wilson JF, Hayward C, Rudan I, Rudd PM, Wright AF, Lauc G: Polymorphisms in B3GAT1, SLC9A9 and MGAT5 are associated with variation within the human plasma N-glycome of 3533 European adults. Hum Mol Genet 2011
    PubMed Abstract
  • Wei W, Hemani G, Hicks AA, Vitart V, Cabrera-Cardenas C, Navarro P, Huffman J, Hayward C, Knott SA, Rudan I, Pramstaller PP, Wild SH, Wilson JF, Campbell H, Dunlop MG, Hastie N, Wright AF, Haley CS: Characterisation of genome-wide association epistasis signals for serum uric Acid in human population isolates. PLoS One 6:e23836, 2011.
    PubMed Abstract
  • Pucic M, Knezevic A, Vidic J, Adamczyk B, Novokmet M, Polasek O, Gornik O, Supraha-Goreta S, Wormald MR, Redzic I, Campbell H, Wright A, Hastie ND, Wilson JF, Rudan I, Wuhrer M, Rudd PM, Josic D, Lauc G: High throughput isolation and glycosylation analysis of IgG - variability and heritability of the IgG glycome in three isolated human populations. Mol Cell Proteomics 2011. epub
    PubMed Abstract
  • Smith NL, Huffman JE, Strachan DP, Huang J, Dehghan A, Trompet S, Lopez LM, Shin SY, Baumert J, Vitart V, Bis JC, Wild SH, Rumley A, Yang Q, Uitterlinden AG, Stott DJ, Davies G, Carter AM, Thorand B, Polasek O, McKnight B, Campbell H, Rudnicka AR, Chen MH, Buckley BM, Harris SE, Peters A, Pulanic D, Lumley T, de Craen AJ, Liewald DC, Gieger C, Campbell S, Ford I, Gow AJ, Luciano M, Porteous DJ, Guo X, Sattar N, Tenesa A, Cushman M, Slagboom PE, Visscher PM, Spector TD, Illig T, Rudan I, Bovill EG, Wright AF, McArdle WL, Tofler G, Hofman A, Westendorp RG, Starr JM, Grant PJ, Karakas M, Hastie ND, Psaty BM, Wilson JF, Lowe GD, O'Donnell CJ, Witteman JC, Jukema JW, Deary IJ, Soranzo N, Koenig W, Hayward C: Genetic predictors of fibrin d-dimer levels in healthy adults. Circulation 123:1864-1872, 2011.
    PubMed Abstract
  • Girotto G, Pirastu N, Sorice R, Biino G, Campbell H, d'Adamo AP, Hastie ND, Nutile T, Polasek O, Portas L, Rudan I, Ulivi S, Zemunik T, Wright AF, Ciullo M, Hayward C, Pirastu M, Gasparini P: Hearing function and thresholds: a genome-wide association study in European isolated populations identifies new loci and pathways. J Med Genet 48(6): 369-74,  2011.
    PubMed Abstract
  • Burn, S.F.; Webb, A.; Berry, R.L.; Davies, J.A.; Ferrer-Vaquer, A.; Hadjantonakis, A.K.; Hastie, N.D. and Hohenstein, P. Calcium/NFAT signalling promotes early nephrogenesis. Dev.Biol.352(2):288-98, 2011
    PubMed Abstract
  • Boger CA, Chen MH, Tin A, Olden M, Kottgen A, de Boer IH, Fuchsberger C, O'Seaghdha CM, Pattaro C, Teumer A, Liu CT, Glazer NL, Li M, O'Connell JR, Tanaka T, Peralta CA, Kutalik Z, Luan J, Zhao JH, Hwang SJ, Akylbekova E, Kramer H, van der HP, Smith AV, Lohman K, de Andrade M, Hayward C, Kollerits B, Tonjes A, Aspelund T, Ingelsson E, Eiriksdottir G, Launer LJ, Harris TB, Shuldiner AR, Mitchell BD, Arking DE, Franceschini N, Boerwinkle E, Egan J, Hernandez D, Reilly M, Townsend RR, Lumley T, Siscovick DS, Psaty BM, Kestenbaum B, Haritunians T, Bergmann S, Vollenweider P, Waeber G, Mooser V, Waterworth D, Johnson AD, Florez JC, Meigs JB, Lu X, Turner ST, Atkinson EJ, Leak TS, Aasarod K, Skorpen F, Syvanen AC, Illig T, Baumert J, Koenig W, Kramer BK, Devuyst O, Mychaleckyj JC, Minelli C, Bakker SJ, Kedenko L, Paulweber B, Coassin S, Endlich K, Kroemer HK, Biffar R, Stracke S, Volzke H, Stumvoll M, Magi R, Campbell H, Vitart V, Hastie ND, Gudnason V, Kardia SL, Liu Y, Polasek O, Curhan G, Kronenberg F, Prokopenko I, Rudan I, Arnlov J, Hallan S, Navis G, Parsa A, Ferrucci L, Coresh J, Shlipak MG, Bull SB, Paterson NJ, Wichmann HE, Wareham NJ, Loos RJ, Rotter JI, Pramstaller PP, Cupples LA, Beckmann JS, Yang Q, Heid IM, Rettig R, Dreisbach AW, Bochud M, Fox CS, Kao WH: CUBN is a gene locus for albuminuria. J Am Soc Nephrol 22:555-570, 2011.
    PubMed Abstract
  • Berry, R.; Harewood, L.; Pei, L.; Fisher, M.; Brownstein, D.; Ross, A.; Alaynick, W.A.; Moss, J.; Hastie, N.D.; Hohenstein, P.; Davies, J.A.; Evans, R.M. and Fitzpatrick, D.R. Esrrg functions in early branch generation of the ureteric bud and is essential for normal development of the renal papilla.
    Hum.Mol Genet.     20(5):917-926, 2011
  • PubMed Abstract
  • Carrasquillo, M.M.; Belbin, O.; Zou, F.; Allen, M.; Ertekin-Taner, N.; Ansari, M.; Wilcox, S.L.; Kashino, M.R.; Ma, L.; Younkin, L.H.; Younkin, S.G.; Younkin, C.S.; Dincman, T.A.; Howard, M.E.; Howell, C.C.; Stanton, C.M.; Watson, C.M.; Crump, M.; Vitart, V.; Hayward, C.; Hastie, N.D.; Rudan, I.; Campbell, H.; Polasek, O.; Brown, K.; Passmore, P.; Craig, D.; McGuinness, B.; Todd, S.; Kehoe, P.G.; Mann, D.M.; Smith, A.D.; Beaumont, H.; Warden, D.; Holmes, C.; Heun, R.; Kolsch, H.; Kalsheker, N.; Pankratz, V.S.; Dickson, D.W.; Graff-Radford, N.R.; Petersen, R.C.; Wright, A.F.; Younkin, S.G. and Morgan, K. Concordant association of insulin degrading enzyme gene (IDE) variants with IDE mRNA, Abeta, and Alzheimer's disease. PLoS One. 5(1):e8764, 2010
    PubMed Abstract
  • Essafi, A. and Hastie, N.D. WT1 the Oncogene: A Tale of Death and HtrA. Mol.Cell 37(2):153-155, 2010
    PubMed Abstract
  • Igl, W.; Johansson, A.; Wilson, J.F.; Wild, S.H.; Polasek, O.; Hayward, C.; Vitart, V.; Hastie, N.; Rudan, P.; Gnewuch, C.; Schmitz, G.; Meitinger, T.; Pramstaller, P.P.; Hicks, A.A.; Oostra, B.A.; van Duijn, C.M.; Rudan, I.; Wright, A.; Campbell, H. and Gyllensten, U. Modeling of environmental effects in genome-wide association studies identifies SLC2A2 and HP as novel loci influencing serum cholesterol levels. PLoS Genet. 6(1):e1000798, 2010
    PubMed Abstract
  • Navarro, P.; Vitart, V.; Hayward, C.; Tenesa, A.; Zgaga, L.; Juricic, D.; Polasek, O.; Hastie, N.D.; Rudan, I.; Campbell, H.; Wright, A.F.; Haley, C.S. and Knott, S.A. Genetic comparison of a Croatian isolate and CEPH European founders. Genet.Epidemiol 34(2):140-5, 2010
    PubMed Abstract
  • Ratelade, J.; Arrondel, C.; Hamard, G.; Garbay, S.; Harvey, S.; Biebuyck, N.; Schulz, H.; Hastie, N.; Pontoglio, M.; Gubler, M.C.; Antignac, C. and Heidet, L. A MURINE MODEL OF DENYS-DRASH SYNDROME REVEALS NOVEL TRANSCRIPTIONAL TARGETS OF WT1 IN PODOCYTES.
    Hum.Mol.Genet.     19(1):1-15, 2010
    PubMed Abstract
  • Aulchenko, Y.S.; Ripatti, S.; Lindqvist, I.; Boomsma, D.; Heid, I.M.; Pramstaller, P.P.; Penninx, B.W.; Janssens, A.C.; Wilson, J.F.; Spector, T.; Martin, N.G.; Pedersen, N.L.; Kyvik, K.O.; Kaprio, J.; Hofman, A.; Freimer, N.B.; Jarvelin, M.R.; Gyllensten, U.; Campbell, H.; Rudan, I.; Johansson, A.; Marroni, F.; Hayward, C.; Vitart, V.; Jonasson, I.; Pattaro, C.; Wright, A.; Hastie, N.; Pichler, I.; Hicks, A.A.; Falchi, M.; Willemsen, G.; Hottenga, J.J.; de Geus, E.J.; Montgomery, G.W.; Whitfield, J.; Magnusson, P.; Saharinen, J.; Perola, M.; Silander, K.; Isaacs, A.; Sijbrands, E.J.; Uitterlinden, A.G.; Witteman, J.C.; Oostra, B.A.; Elliott, P.; Ruokonen, A.; Sabatti, C.; Gieger, C.; Meitinger, T.; Kronenberg, F.; Doring, A.; Wichmann, H.E.; Smit, J.H.; McCarthy, M.I.; van Duijn, C.M. and Peltonen, L. Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. Nat Genet 41(1):47-55, 2009
    PubMed Abstract
  • Barbalic, M.; Narancic, N.S.; Skaric-Juric, T.; Salihovic, M.P.; Klaric, I.M.; Lauc, L.B.; Janicijevic, B.; Farrall, M.; Rudan, I.; Campbell, H.; Wright, A.F.; Hastie, N.D. and Rudan, P. A quantitative trait locus for SBP maps near KCNB1 and PTGIS in a population isolate.
    Am.J Hypertens.     22(6):663-668, 2009
    PubMed Abstract
  • Hicks, A.A.; Pramstaller, P.P.; Johansson, A.; Vitart, V.; Rudan, I.; Ugocsai, P.; Aulchenko, Y.; Franklin, C.S.; Liebisch, G.; Erdmann, J.; Jonasson, I.; Zorkoltseva, I.V.; Pattaro, C.; Hayward, C.; Isaacs, A.; Hengstenberg, C.; Campbell, S.; Gnewuch, C.; Janssens, A.C.; Kirichenko, A.V.; Konig, I.R.; Marroni, F.; Polasek, O.; Demirkan, A.; Kolcic, I.; Schwienbacher, C.; Igl, W.; Biloglav, Z.; Witteman, J.C.; Pichler, I.; Zaboli, G.; Axenovich, T.I.; Peters, A.; Schreiber, S.; Wichmann, H.E.; Schunkert, H.; Hastie, N.; Oostra, B.A.; Wild, S.H.; Meitinger, T.; Gyllensten, U.; van Duijn, C.M.; Wilson, J.F.; Wright, A.; Schmitz, G. and Campbell, H. Genetic determinants of circulating sphingolipid concentrations in European populations. PLoS Genet. 5(10):e1000672, 2009
    PubMed Abstract
  • Johansson, A.; Marroni, F.; Hayward, C.; Franklin, C.S.; Kirichenko, A.V.; Jonasson, I.; Hicks, A.A.; Vitart, V.; Isaacs, A.; Axenovich, T.; Campbell, S.; Floyd, J.; Hastie, N.; Knott, S.; Lauc, G.; Pichler, I.; Rotim, K.; Wild, S.H.; Zorkoltseva, I.V.; Wilson, J.F.; Rudan, I.; Campbell, H.; Pattaro, C.; Pramstaller, P.; Oostra, B.A.; Wright, A.F.; van Duijn, C.M.; Aulchenko, Y.S. and Gyllensten, U. Linkage and Genome-wide Association Analysis of Obesity-related Phenotypes: Association of Weight With the MGAT1 Gene. Obesity.(Silver.Spring), 2009
    PubMed Abstract