Research Biographies
PROFESSOR NICHOLAS HASTIE, CBE FRS FRSE
Medical and Developmental Genetics
Director of the MRC Human Genetics Unit
Director of the Institute of Genetics and Molecular Medicine (IGMM)
Contact Details
| E-mail address: | n.hastie@igmm.ed.ac.uk |
| Telephone: | +44 (0)131 332 2471 |
| Fax: | +44 (0)131 467 8456 |
| Address: | MRC Human Genetics Unit MRC IGMM, University of Edinburgh Western General Hospital, Crewe Road, Edinburgh EH4 2XU |
| Research Programme: | Cancer, Development and Adult Tissue Maintenance |
Key/Selected Publications
- Chau YY, Brownstein D, Mjoseng H, Lee WC, Buza-Vidas N, Nerlov C, Jacobsen SE, Perry P, Berry R, Thornburn A, Sexton D, Morton N, Hohenstein P, Freyer E, Samuel K, Van't Hof R, Hastie N: Acute multiple organ failure in adult mice deleted for the developmental regulator wt1
PLoS Genet 7:e1002404, 2011.
PubMed Abstract - Essafi A, Webb A, Berry RL, Slight J, Burn SF, Spraggon L, Velecela V, Martinez-Estrada OM, Wiltshire JH, Roberts SG, Brownstein D, Davies JA, Hastie ND, Hohenstein P: A Wt1-Controlled Chromatin Switching Mechanism Underpins Tissue-Specific Wnt4 Activation and Repression
Dev Cell 2011
PubMed Abstract - Guadix JA, Ruiz-Villalba A, Lettice L, Velecela V, Munoz-Chapuli R, Hastie ND, Perez-Pomares JM, Martinez-Estrada OM: Wt1 controls retinoic acid signalling in embryonic epicardium through transcriptional activation of Raldh2. Development 138:1093-1097, 2011.
PubMed Abstract - Dudnakova, T.; Spraggon, L.; Slight, J. and Hastie, N. Actin: a novel interaction partner of WT1 influencing its cell dynamic properties. Oncogene 29(7):1085-92, 2010
PubMed Abstract - Martinez-Estrada, O.M.; Lettice, L.A.; Essafi, A.; Guadix, J.A.; Slight, J.; Velecela, V.; Hall, E.; Reichmann, J.; Devenney, P.S.; Hohenstein, P.; Hosen, N.; Hill, R.E.; Munoz-Chapuli, R. and Hastie, N.D. Wt1 is required for cardiovascular progenitor cell formation through transcriptional control of Snail and E-cadherin Nat.Genet. 42(1):89-93, 2010
PubMed Abstract
Recent Publications
- Kottgen A, Albrecht E, Teumer A, Vitart V, Krumsiek J, Hundertmark C, Pistis G, Ruggiero D, …….Hayward C, Zemunik T, Huffman J, ……...Hastie N, Balkau B,....Rivadeneira F, …………, Schurmann C, Budde K, Ernst F, Farrington SM, ....... …… Campbell H, Rudan I, ….., Deary IJ, …….Schipf S, Dunlop MG, Tonjes A, Ripatti S, Soranzo N, Toniolo D, Chasman DI, .....Caulfield M, Bochud M, and Gieger C. Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nat. Genet. 45: 145-154. 2013
PubMed Abstract - Chau YY and Hastie ND. The role of Wt1 in regulating mesenchyme in cancer, development, and tissue homeostasis
Trends Genet. 28: 515-524.2012
PubMed Abstract - Chasman DI, Fuchsberger C, Pattaro C, Teumer A, Boger CA, Endlich K, Olden M, ....Rao M, Hu F, Demirkan A, Oostra BA, de AM, Turner ST, Ding J, Andrews JS, ...... Wright AF, Campbell H, Ellinghaus D, Nothlings U, Jacobs G, Biffar R, Ernst F, ...........Hastie N, Vitart V, Helmer C, Wang JJ, Stengel B, Ruggiero D, Bergmann S, Kahonen M, Viikari J, Nikopensius T, Province M, Ketkar S, Colhoun H, Doney A, ...... Probst-Hensch NM, Kronenberg F, Toniolo D, Gudnason V, Shuldiner AR, .....Rudan I, Gyllensten U, Wilson JF, ....., Hayward C, Ridker PM, Parsa A, Bochud M, Heid IM, Kao WH, Fox CS, Kottgen A: Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function. Hum Mol Genet 2012.
PubMed Abstract - Nagamine Y, Pong-Wong R, Navarro P, Vitart V, Hayward C, Rudan I, Campbell H, Wilson J, Wild S, Hicks AA, Pramstaller PP, Hastie N, Wright AF, Haley CS: Localising Loci underlying Complex Trait Variation Using Regional Genomic Relationship Mapping. PLoS One 7:e46501, 2012.
PubMed Abstract - Pattaro C, Kottgen A, Teumer A, Garnaas M, Boger CA, Fuchsberger C, Olden ...........Wright AF, Campbell H, Ellinghaus D, Nothlings U, Jacobs G, Biffar R, Endlich ..........YS, Polasek O, Hastie N, Vitart V, Helmer C, Wang JJ, Ruggiero D, Bergmann S, Kahonen M, Viikari J, Nikopensius T, ............NM, Kronenberg F, Toniolo D, Gudnason V, Shuldiner AR, Coresh J, Schmidt R, Ferrucci L, Siscovick DS, van Duijn CM, Borecki I, Kardia SL, Liu Y, Curhan GC, Rudan I, Gyllensten U, Wilson ........ Hayward C, Ridker P, Parsa A, Bochud M, Heid IM, Goessling W, Chasman DI, Kao WH, Fox CS: Genome-wide association and functional follow-up reveals new Loci for kidney function
PLoS Genet 8:e1002584, 2012.
PubMed Abstract - Demirkan A, van Duijn CM, Ugocsai P, Isaacs A, Pramstaller PP, Liebisch G, Wilson JF, Johansson A, Rudan I, Aulchenko YS, .......... Huffman J, Hastie ND, Uitterlinden A, Franke L, Franklin CS, Vitart V, Nelson CP, Preuss M, Bis JC, O'Donnell CJ, Franceschini N, Witteman JC, Axenovich T, Oostra BA, Meitinger T, Hicks AA, Hayward C, Wright AF, Gyllensten U, Campbell H, Schmitz G: Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations
PLoS Genet 8:e1002490, 2012.
PubMed Abstract - Veikkolainen V, Naillat F, Railo A, Chi L, Manninen A, Hohenstein P, Hastie N, Vainio S, Elenius K: ErbB4 Modulates Tubular Cell Polarity and Lumen Diameter during Kidney Development. J Am Soc Nephrol 2011. PubMed Abstract
- Huffman JE, Knezevic A, Vitart V, Kattla J, Adamczyk B, Novokmet M, Igl W, Pucic M, Zgaga L, Johannson A, Redzic I, Gornik O, Zemunik T, Polasek O, Kolcic I, Pehlic M, Koeleman CA, Campbell S, Wild SH, Hastie ND, Campbell H, Gyllensten U, Wuhrer M, Wilson JF, Hayward C, Rudan I, Rudd PM, Wright AF, Lauc G: Polymorphisms in B3GAT1, SLC9A9 and MGAT5 are associated with variation within the human plasma N-glycome of 3533 European adults. Hum Mol Genet 2011
PubMed Abstract
- Wei W, Hemani G, Hicks AA, Vitart V, Cabrera-Cardenas C, Navarro P, Huffman J, Hayward C, Knott SA, Rudan I, Pramstaller PP, Wild SH, Wilson JF, Campbell H, Dunlop MG, Hastie N, Wright AF, Haley CS: Characterisation of genome-wide association epistasis signals for serum uric Acid in human population isolates. PLoS One 6:e23836, 2011.
PubMed Abstract
- Pucic M, Knezevic A, Vidic J, Adamczyk B, Novokmet M, Polasek O, Gornik O, Supraha-Goreta S, Wormald MR, Redzic I, Campbell H, Wright A, Hastie ND, Wilson JF, Rudan I, Wuhrer M, Rudd PM, Josic D, Lauc G: High throughput isolation and glycosylation analysis of IgG - variability and heritability of the IgG glycome in three isolated human populations. Mol Cell Proteomics 2011. epub
PubMed Abstract
- Smith NL, Huffman JE, Strachan DP, Huang J, Dehghan A, Trompet S, Lopez LM, Shin SY, Baumert J, Vitart V, Bis JC, Wild SH, Rumley A, Yang Q, Uitterlinden AG, Stott DJ, Davies G, Carter AM, Thorand B, Polasek O, McKnight B, Campbell H, Rudnicka AR, Chen MH, Buckley BM, Harris SE, Peters A, Pulanic D, Lumley T, de Craen AJ, Liewald DC, Gieger C, Campbell S, Ford I, Gow AJ, Luciano M, Porteous DJ, Guo X, Sattar N, Tenesa A, Cushman M, Slagboom PE, Visscher PM, Spector TD, Illig T, Rudan I, Bovill EG, Wright AF, McArdle WL, Tofler G, Hofman A, Westendorp RG, Starr JM, Grant PJ, Karakas M, Hastie ND, Psaty BM, Wilson JF, Lowe GD, O'Donnell CJ, Witteman JC, Jukema JW, Deary IJ, Soranzo N, Koenig W, Hayward C: Genetic predictors of fibrin d-dimer levels in healthy adults. Circulation 123:1864-1872, 2011.
PubMed Abstract
- Girotto G, Pirastu N, Sorice R, Biino G, Campbell H, d'Adamo AP, Hastie ND, Nutile T, Polasek O, Portas L, Rudan I, Ulivi S, Zemunik T, Wright AF, Ciullo M, Hayward C, Pirastu M, Gasparini P: Hearing function and thresholds: a genome-wide association study in European isolated populations identifies new loci and pathways. J Med Genet 48(6): 369-74, 2011.
PubMed Abstract - Burn, S.F.; Webb, A.; Berry, R.L.; Davies, J.A.; Ferrer-Vaquer, A.; Hadjantonakis, A.K.; Hastie, N.D. and Hohenstein, P. Calcium/NFAT signalling promotes early nephrogenesis. Dev.Biol.352(2):288-98, 2011
PubMed Abstract
- Boger CA, Chen MH, Tin A, Olden M, Kottgen A, de Boer IH, Fuchsberger C, O'Seaghdha CM, Pattaro C, Teumer A, Liu CT, Glazer NL, Li M, O'Connell JR, Tanaka T, Peralta CA, Kutalik Z, Luan J, Zhao JH, Hwang SJ, Akylbekova E, Kramer H, van der HP, Smith AV, Lohman K, de Andrade M, Hayward C, Kollerits B, Tonjes A, Aspelund T, Ingelsson E, Eiriksdottir G, Launer LJ, Harris TB, Shuldiner AR, Mitchell BD, Arking DE, Franceschini N, Boerwinkle E, Egan J, Hernandez D, Reilly M, Townsend RR, Lumley T, Siscovick DS, Psaty BM, Kestenbaum B, Haritunians T, Bergmann S, Vollenweider P, Waeber G, Mooser V, Waterworth D, Johnson AD, Florez JC, Meigs JB, Lu X, Turner ST, Atkinson EJ, Leak TS, Aasarod K, Skorpen F, Syvanen AC, Illig T, Baumert J, Koenig W, Kramer BK, Devuyst O, Mychaleckyj JC, Minelli C, Bakker SJ, Kedenko L, Paulweber B, Coassin S, Endlich K, Kroemer HK, Biffar R, Stracke S, Volzke H, Stumvoll M, Magi R, Campbell H, Vitart V, Hastie ND, Gudnason V, Kardia SL, Liu Y, Polasek O, Curhan G, Kronenberg F, Prokopenko I, Rudan I, Arnlov J, Hallan S, Navis G, Parsa A, Ferrucci L, Coresh J, Shlipak MG, Bull SB, Paterson NJ, Wichmann HE, Wareham NJ, Loos RJ, Rotter JI, Pramstaller PP, Cupples LA, Beckmann JS, Yang Q, Heid IM, Rettig R, Dreisbach AW, Bochud M, Fox CS, Kao WH: CUBN is a gene locus for albuminuria. J Am Soc Nephrol 22:555-570, 2011.
PubMed Abstract
- Berry, R.; Harewood, L.; Pei, L.; Fisher, M.; Brownstein, D.; Ross, A.; Alaynick, W.A.; Moss, J.; Hastie, N.D.; Hohenstein, P.; Davies, J.A.; Evans, R.M. and Fitzpatrick, D.R. Esrrg functions in early branch generation of the ureteric bud and is essential for normal development of the renal papilla.
Hum.Mol Genet. 20(5):917-926, 2011 - PubMed Abstract
- Carrasquillo, M.M.; Belbin, O.; Zou, F.; Allen, M.; Ertekin-Taner, N.; Ansari, M.; Wilcox, S.L.; Kashino, M.R.; Ma, L.; Younkin, L.H.; Younkin, S.G.; Younkin, C.S.; Dincman, T.A.; Howard, M.E.; Howell, C.C.; Stanton, C.M.; Watson, C.M.; Crump, M.; Vitart, V.; Hayward, C.; Hastie, N.D.; Rudan, I.; Campbell, H.; Polasek, O.; Brown, K.; Passmore, P.; Craig, D.; McGuinness, B.; Todd, S.; Kehoe, P.G.; Mann, D.M.; Smith, A.D.; Beaumont, H.; Warden, D.; Holmes, C.; Heun, R.; Kolsch, H.; Kalsheker, N.; Pankratz, V.S.; Dickson, D.W.; Graff-Radford, N.R.; Petersen, R.C.; Wright, A.F.; Younkin, S.G. and Morgan, K. Concordant association of insulin degrading enzyme gene (IDE) variants with IDE mRNA, Abeta, and Alzheimer's disease. PLoS One. 5(1):e8764, 2010
PubMed Abstract - Essafi, A. and Hastie, N.D. WT1 the Oncogene: A Tale of Death and HtrA. Mol.Cell 37(2):153-155, 2010
PubMed Abstract - Igl, W.; Johansson, A.; Wilson, J.F.; Wild, S.H.; Polasek, O.; Hayward, C.; Vitart, V.; Hastie, N.; Rudan, P.; Gnewuch, C.; Schmitz, G.; Meitinger, T.; Pramstaller, P.P.; Hicks, A.A.; Oostra, B.A.; van Duijn, C.M.; Rudan, I.; Wright, A.; Campbell, H. and Gyllensten, U. Modeling of environmental effects in genome-wide association studies identifies SLC2A2 and HP as novel loci influencing serum cholesterol levels. PLoS Genet. 6(1):e1000798, 2010
PubMed Abstract - Navarro, P.; Vitart, V.; Hayward, C.; Tenesa, A.; Zgaga, L.; Juricic, D.; Polasek, O.; Hastie, N.D.; Rudan, I.; Campbell, H.; Wright, A.F.; Haley, C.S. and Knott, S.A. Genetic comparison of a Croatian isolate and CEPH European founders. Genet.Epidemiol 34(2):140-5, 2010
PubMed Abstract - Ratelade, J.; Arrondel, C.; Hamard, G.; Garbay, S.; Harvey, S.; Biebuyck, N.; Schulz, H.; Hastie, N.; Pontoglio, M.; Gubler, M.C.; Antignac, C. and Heidet, L. A MURINE MODEL OF DENYS-DRASH SYNDROME REVEALS NOVEL TRANSCRIPTIONAL TARGETS OF WT1 IN PODOCYTES.
Hum.Mol.Genet. 19(1):1-15, 2010
PubMed Abstract