Dr Mary O'Connell: Chromosomes and Gene Expression

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  1. Keegan, L.P.; Leroy, A.; Sproul, D. and O'Connell, M.A. Adenosine deaminases acting on RNA (ADARs): RNA-editing enzymes. Genome Biology 5(2): 209, 2004 PubMed Abstract
  2. Ring, G.M.; O'Connell, M.A. and Keegan, L.P. Purification and assay of recombinant ADAR proteins expressed in the yeast Pichia pastoris or in Escherichia coli. Methods Mol Biol 265:219-238, 2004 PubMed Abstract

  3. Gallo, A.; Keegan, L.P.; Ring, G.M. and O'Connell, M.A. An ADAR that edits transcripts encoding ion channel subunits fuctions as a dimer. EMBO Journal 22(13):3421-3430, 2003
    PubMed Abstract
  4. Gallo, A.; Thomson, E.; Brindle, J.; O'Connell, M.A. and Keegan, L.P. Micro-processing events in the mRNAs identified by DHPLC analysis. Nucleic Acids Research 30(18):3945-3953, 2002
    PubMed Abstract
  5. Keegan, L.P.; Gallo, A. and O'Connell, M.A. The many roles of an RNA editor. Nature Reviews Genetics 2(11): 869-878, 2001
    PubMed Abstract
  6. Keegan, L.P.; Gallo, A. and O'Connell, M.A. Development. Survival is impossible without an editor. Science 290(5497):1707-1709, 2000
    PubMed Abstract
  7. Keegan, L.P.; Gerber, A.P.; Brindle, J.; Leemans, R.; Gallo, A.; Keller, W. and O'Connell, M.A. The Properties of a tRNA-Specific Adenosine Deaminase from Drosophila melanogaster Support an Evolutionary Link between Pre-mRNA Editing and tRNA Modification. Mol Cell Biol 20(3):825-833, 2000
    PubMed Abstract
  8. Palladino, M.J.; Keegan, L.P.; O'Connell, M.A. and Reenan, R.A. A-to-I pre-mRNA Editing in Drosophila is Primarily Involved in Adult Nervous System Function and Integrity. Cell 102:437-449, 2000
    PubMed Abstract
  9. Palladino, M.J.; Keegan, L.P.; O'Connell, M.A. and Reenan, R.A. dADAR, a Drosophila double-stranded RNA-specific adenosine deaminase is highly developmentally regulated and is itself a target of RNA editing. RNA 6:1004-1018, 2000
    PubMed Abstract
  10. Paupard, M.-C.; O'Connell, M.A.; Gerber, A.P. and Zukin, R.S. Patterns of developmental expression of the RNA editing enzyme rADAR2. Neuroscience 95(3):869-879, 2000
    PubMed Abstract
  11. O'Connell, M.A.; Gerber, A. and Keegan, L.P. Purification of Native and Recombinant Double-Stranded RNA-Specific Adenosine Deaminases. Methods: A Companion to Methods in Enzymology 15:51-62, 1998
    PubMed Abstract
  12. Gerber, A.; O'Connell, M.A. and Keller, W. Two forms of human double-stranded RNA-specific editase 1 (hRED1) generated by the insertion of an Alu cassette. RNA 3(5): 453-463, 1997   
    PubMed Abstract
  13. O'Connell, M.A. RNA editing: rewriting receptors. Curr Biol 7(7):R437-9.1997
    PubMed Abstract
  14. O'Connell, M.A.; Gerber, A., and Keller, W. Purification of human double-stranded RNA-specific editase 1 (hRED1) involved in editing of brain glutamate receptor B pre-mRNA. J Biol Chem 272(1):473-478, 1997
    PubMed Abstract
  15. Maas, S.; Melcher, T.; Herb, A.; Seeburg, P.H.; Keller, W.; Krause, S.; Higuchi, M. and O'Connell, M.A. Structural requirements for RNA editing in glutamate receptor pre-mRNAs by recombinant double-stranded RNA adenosine deaminase. J Biol Chem 271(21):12221-12226, 1996 
    PubMed Abstract

 



 

  1. Nucleic Acid Editing: From Germline to the CNS
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Publications List

  1. Barraud P, Heale BS, O'Connell MA, Allain FH: Solution structure of the N-terminal dsRBD of Drosophila ADAR and interaction studies with RNA
    Biochimie 94:1499-1509, 2012.
    PubMed Abstract
  2. Carpenter, J.A.; Keegan, L.; Wilfert, L.; O'Connell, M.A. and Jiggins, F.M. Evidence for ADAR-induced hypermutation of the Drosophila sigma virus (Rhabdoviridae). BMC Genet 10(1):75, 2009 PubMed Abstract
  3. Galeano, F.; Leroy, A.; Rossetti, C.; Gromova, I.; Gautier, P.; Keegan, L.P.; Massimi, L.; Di Rocco, C.; O'Connell, M.A. and Gallo, A. Human BLCAP transcript: New editing events in normal and cancerous tissues. Int.J Cancer e-pub Nov 11, 2009 PubMed Abstract
  4. Heale, B.S.; Keegan, L.P.; McGurk, L.; Michlewski, G.; Brindle, J.; Stanton, C.M.; Caceres, J.F. and O'Connell, M.A. Editing independent effects of ADARs on the miRNA/siRNA pathways.
    EMBO J.     28(20):3145-3156, 2009 PubMed Abstract
  5. Heale, B.S.; Keegan, L.P. and O'Connell, M.A. ADARs have effects beyond RNA editing. Cell Cycle 8(24), 2009 PubMed Abstract
  6. Marcucci, R.; Romano, M.; Feiguin, F.; O'Connell, M.A. and Baralle FE. Dissecting the splicing mechanism of the Drosophila editing enzyme; dADAR. Nucleic Acids Res e-pub Jan 19, 2009
    PubMed Abstract
  7. Palavicini, J.P.; O'Connell, M.A. and Rosenthal, J.J. An extra double-stranded RNA binding domain confers high activity to a squid RNA editing enzyme. RNA 15(6):1208-1218, 2009 PubMed Abstract
  8. Cenci, C.; Barzotti, R.; Galeano, F.; Corbelli, S.; Rota, R.; Massimi, L.; Di Rocco, C.; O'Connell, M.A. and Gallo, A. Down-regulation of RNA editing in pediatric astrocytomas: ADAR2 editing activity inhibits cell migration and proliferation. Journal of Biological Chemistry 283(11):7251-7260, 2008
    PubMed Abstract
  9. Keegan, L.P.; Rosenthal, J.J.; Roberson, L.M. and O'Connell, M.A. Purification and assay of ADAR activity. Methods Enzymol 424:301-317, 2007
    PubMed Abstract
  10. McGurk, L.; Morrison, H.; Keegan, L.P.; Sharpe, J. and O'Connell, M.A. Three-Dimensional Imaging of Drosophila melanogaster. PLoS ONE 2(9):e834, 2007 PubMed Abstract
  11. O'Connell, M.A. and Keegan, L.P. Drosha versus ADAR;wrangling over pri-miRNA. Nature Structural & Molecular Biology 13(1):3-4, 2006
    PubMed Abstract
  12. Clutterbuck, D.R.; Leroy, A.; O'Connell, M. and Semple, C.A. A Bioinformatic Screen for Novel A-I RNA Editing Sites Reveals Re-Coding Editing in BC10. Bioinformatics 21(11):2590-5, 2005
    PubMed Abstract
  13. Desterro, J.M.; Keegan, L.P.; Jaffray, E.; Hay, R.T.; O'Connell, M.A. and Carmo-Fonseca, M. SUMO-1 Modification Alters ADAR1 Editing Activity. Mol Biol Cell 16(11): 5115-5126, 2005
    PubMed Abstract
  14. Keegan, L.P.; Brindle, J.; Gallo, A.; Leroy, A.; Reenan, R.A. and O’Connell, M.A. Tuning of RNA editing by ADAR is required in Drosophila. EMBO Journal  24(12):2183-93, 2005
    PubMed Abstract
  15. Scadden, A.D.J. and O'Connell, M.A. Cleavage of dsRNAs hyper-edited by ADARs occurs at preferred editing sites. Nucleic Acids Research 33(18):5954-5964, 2005
    PubMed Abstract