Professor Malcolm Dunlop: Colon Cancer Genetics Group and Academic Coloproctology

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Colon Cancer Genetics and Chemoprevention

 

 

  1. Tomlinson, I.P.; Webb, E.; Carvajal-Carmona, L.; 58 others, *Campbell, H.; *Dunlop, M.G. and *Houlston, R. A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3.
    Nat Genet     40(5):623-630, 2008 *Joint senior authors.
    PubMed Abstract

  2. Owen, R.M.; Baker, R.D.; Bader, S.; Dunlop, M.G. and Nicholl, I.D. The identification of a novel alternatively spliced form of the MBD4 DNA glycosylase. Oncol Rep 17(1):111-116, 2007
    PubMed Abstract

  3. Prendergast, J.G.; Campbell, H.; Gilbert, N.; Dunlop, M.G.; Bickmore, W.A. and Semple, C.A. Chromatin structure and evolution in the human genome.
    BMC Evol Biol 7:72, 2007
    PubMed Abstract

  4. Zanke, B.W.; Greenwood, C.M.; Rangrej, J.; Kustra, R.; Tenesa, A.; Farrington, S.M.; Prendergast, J.; Olschwang, S.; Chiang, T.; Crowdy, E.; Ferretti, V.; Laflamme, P.; Sundararajan, S.; Roumy, S.; Olivier, J.F.; Robidoux, F.; Sladek, R.; Montpetit, A.; Campbell, P.; Bezieau, S.; O'Shea, A.M.; Zogopoulos, G.; Cotterchio, M.; Newcomb, P.; McLaughlin, J.; Younghusband, B.; Green, R.; Green, J.; Porteous, M.E.; Campbell, H.; Blanche, H.; Sahbatou, M.; Tubacher, E.; Bonaiti-Pellie, C.; Buecher, B.; Riboli, E.; Kury, S.; Chanock, S.J.; Potter, J.; Thomas, G.; Gallinger, S.; Hudson, T.J. and
    Dunlop, M.G.     Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24.
    Nat Genet 39(8):989-994, 2007
    PubMed Abstract

  5. Theodoratou, E.; Kyle, J.; Cetnarskyj, R.; Farrington, S.M.; Tenesa, A.; Barnetson, R.; Porteous, M.; Dunlop, M. and Campbell, H. Dietary flavonoids and the risk of colorectal cancer. Cancer Epidemiol Biomarkers Prev 16(4):684-693, 2007 PubMed Abstract

  6. Theodoratou, E.; McNeill, G.; Cetnarskyj, R.; Farrington, S.M.; Tenesa, A.; Barnetson, R.; Porteous, M.; Dunlop, M. and Campbell, H. Dietary fatty acids and colorectal cancer: a case-control study. Am J Epidemiol 166(2):181-195, 2007 
    PubMed Abstract

  7. Barnetson, R.A.; Tenesa, A.; Farrington, S.M.; Nicholl, I.D.; Cetnarskyj, R.; Porteous, M.E.; Campbell, H. and Dunlop, M.G. Identification and survival of carriers of mutations in DNA mismatch-repair genes in colon cancer.
    N Engl J Med     354(26):2751-2763, 2006
    PubMed Abstract

  8. Tenesa, A. and Dunlop, M.G. Validity of tagging SNPs across populations for association studies.
    Eur J Hum Genet     14(3):357-363, 2006
    PubMed Abstract

  9. Farrington, S.M.; Tenesa, A.; Barnetson, R.; Wiltshire, A.; Prendergast, J.; Porteous, M.; Campbell, H. and Dunlop, M.G. Germline susceptibility to colorectal cancer due to base-excision repair gene defects. Am J Hum Genet 77(1):112-119, 2005 PubMed Abstract

 

 

 

  1. Chemoprevention of Colorectal Cancer:
    Dr Lesley Stark
  2. Cancer Genetics (Edinburgh Cancer Research Centre)
  • Publications (this page)

 

 

Publications

Selected Recent Genetic Susceptibility Papers

  1. Tenesa, A.; Campbell, H.; Theodoratou, E.; Dunlop, L.; Cetnarskyj, R.; Farrington, S.M. and Dunlop, M.G. Common genetic variants at the MC4R locus are associated with obesity, but not with dietary energy intake or colorectal cancer in the Scottish population. Int J Obes 33(2):284-288, 2009
    PubMed Abstract

  2. Barnetson, R.A.; Cartwright, N.; van Vliet, A.; Haq, N.; Drew, K.; Farrington, S.; Williams, N.; Warner, J.; Campbell, H.; Porteous, M.E. and Dunlop, M.G. Classification of ambiguous mutations in DNA mismatch repair genes identified in a population-based study of colorectal cancer. Hum Mutat 29(3):367-374, 2008 
    PubMed Abstract

  3. Houlston, R.S.; Webb, E.; Broderick, P.;
    47 others and Dunlop, M.G. Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer.
    Nat Genet 40(12):1426-1435, 2008
    PubMed Abstract

  4. Jaeger, E.; Webb, E.; Howarth, K.; Carvajal-Carmona, L.; Rowan, A.; Broderick, P.; Walther, A.; Spain, S.; Pittman, A.; Kemp, Z.; Sullivan, K.; Heinimann, K.; Lubbe, S.; Domingo, E.; Barclay, E.; Martin, L.; Gorman, M.; Chandler, I.; Vijayakrishnan, J.; Wood, W.; Papaemmanuil, E.; Penegar, S.; Qureshi, M.; Farrington, S.; Tenesa, A.; Cazier, J.B.; Kerr, D.; Gray, R.; Peto, J.; Dunlop, M.; Campbell, H.; Thomas, H.; Houlston, R. and Tomlinson, I. Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk.
    Nat Genet 40(1):26-28, 2008
    PubMed Abstract

  5. McQuillan, R.; Leutenegger, A.L.; Abdel-Rahman, R.; Franklin, C.S.; Pericic, M.; Barac-Lauc, L.; Smolej-Narancic, N.; Janicijevic, B.; Polasek, O.; Tenesa, A.; Macleod, A.K.; Farrington, S.M.; Rudan, P.; Hayward, C.; Vitart, V.; Rudan, I.; Wild, S.H.; Dunlop, M.G.; Wright, A.F.; Campbell, H. and Wilson, J.F. Runs of homozygosity in European populations.
    Am J Hum Genet 83(3):359-372, 2008
    PubMed Abstract

  6. Tenesa, A.; Farrington, S.M.; Prendergast, J.G.D.; 35 others and Dunlop, M.G. A genome-wide association scan identifies a new colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21.
    Nat Genet 40(5):631-637, 2008
    PubMed Abstract

  7. Theodoratou, E.; Campbell, H.; Tenesa, A.; McNeill, G.; Cetnarskyj, R.; Barnetson, R.A.; Porteous, M.E.; Dunlop, M.G. and Farrington, S.M. Modification of the associations between lifestyle, dietary factors and colorectal cancer risk by APC variants.
    Carcinogenesis     29(9):1774-1780, 2008 PubMed Abstract

  8. Theodoratou, E.; Farrington, S.M.; Tenesa, A.; McNeill, G.; Cetnarskyj, R.; Barnetson, R.A.; Porteous, M.E.; Dunlop, M.G. and Campbell, H. Modification of the inverse association between dietary vitamin D intake and colorectal cancer risk by a FokI variant supports a chemoprotective action of Vitamin D intake mediated through VDR binding. Int J Cancer 123(9):2170-9, 2008 PubMed Abstract

  9. Theodoratou, E.; Farrington, S.M.; Tenesa, A.; McNeill, G.; Cetnarskyj, R.; Barnetson, R.A.; Porteous, M.E.; Dunlop, M.G. and Campbell, H. Dietary vitamin B6 intake and the risk of colorectal cancer. Cancer Epidemiol Biomarkers Prev 7(1):171-182, 2008
    PubMed Abstract