Professor Alan Wrigh FRCP FRSE FMedScit: Medical and Developmental Genetics

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Quantitative Trait Locus (QTL) Identification in Isolate Populations


 

  1. Campbell, H.; Carothers, A.D.; Rudan, I.; Hayward, C.; Biloglav, Z.; Barac, L.; Pericic, M.; Janicijevic, B.; Smolej-Narancic, N.; Polasek, O.; Kolcic, I.; Weber, J.L.; Hastie, N.D.; Rudan, P. and Wright, A.F. Effects of genome-wide heterozygosity on a range of biomedically relevant human quantitative traits.
    Hum Mol Genet     16(2):233-241, 2007 PubMed Abstract
  2. Wright, A.F. and Hastie, N.D. (eds.) Genes and Common Diseases – Genetics in Modern Medicine. Cambridge University Press, 2007
  3. Carothers, A.D.; Rudan, I.; Kolcic, I.; Polasek, O.; Hayward, C.; Wright, A.F.; Campbell, H.; Teague, P.; Hastie, N.D. and Weber, J.L. Estimating human inbreeding coefficients: comparison of genealogical and marker heterozygosity approaches. Annals of Human Genetics 70(Pt 5):666-676, 2006
    PubMed Abstract
  4. Rudan, I.; Campbell, H.; Carothers, A.D.; Hastie, N.D. and Wright, A.F. Contribution of consanguinuity to polygenic and multifactorial diseases.
    Nat Genet     38(11):1224-1225, 2006 PubMed Abstract
  5. Rudan, I.; Smolej-Narancic, N.; Campbell, H.; Carothers, A.; Wright, A.; Janicijevic, B. and Rudan, P. Inbreeding and the Genetic Complexity of Human Hypertension. Genetics 163(3):1011-1021, 2003
    PubMed Abstract
  6. Wright, A.; Charlesworth, B.; Rudan, I.; Carothers, A. and Campbell, H. A polygenic basis for late-onset disease.
    Trends in Genetics 19(2):97-106, 2003 PubMed Abstract
  7. Deary, I.J.; Whiteman, M.C.; Pattie, A.; Starr, J.M.; Hayward, C.; Wright, A.F.; Carothers, A. and Whalley, L.J. Cognitive change and the APOE e4 allele.
    Nature     418:932, 2002
    PubMed Abstract

 

Collaborations

Other ICMM Programmes

  1. Christopher S. Haley PhD (MRC Programme Leader) Andrew Jackson PhD FRCP (MRC Programme Leader) Colin Semple PhD (MRC Programme Leader) Malcolm Dunlop MD FRCS (Univ. of Edinburgh and MRC Programme Leader).
  2. University of Edinburgh, Edinburgh, UK
    Professor Harry Campbell, Dr. Igor Rudan, Dr. Jim Wilson, Dr. Sarah Wild, Professor Paul McKeigue (Public Health Sciences); Professor Ian Deary (Dept. of Psychology); Dr. Sara Knott (Institute of Evolutionary Biology); Professor Stuart Ralston, Professor Brian Walker, Professor David Webb, Professor Neil Douglas, Dr. Renata Riha, Dr.Albert Tenesa (College of Medicine and Veterinary Medicine)
  3. University of Glasgow, Royal Infirmary, Glasgow, UK
    Professor Gordon Lowe (Department of Medicine)
  4. University of Dundee, Dundee, UK
    Professor Andrew Morris (Diabetes Research Group, Division of Medicine and Therapeutics) and Dr. Colin Palmer (Population Pharmacogenetics Group, Biomedical Research Centre)
  5. University of Split, Croatia
    Dr. Igor Rudan (Public Health Sciences)
  6. University of Zagreb, Croatia
    Dr. Ozren Polasek, Dr. Ivana Kolcic, Dr. Zrinka Biloglav, Dr. Lina Zgaga (Andrija Stampar School of Public Health)
  7. Institute for Anthropological Research, Zagreb, Croatia
    Professor Pavao Rudan, Dr. Branca Janicijevic, Dr. Nina Smolej-Narancic
  8. University of London
    Dr Tony Marinaki (Purine Research Laboratory, KCL) Carl Gustav Carus Medical School, University of Technology Dresden, Germany Juergen Graessler, Martin Aringer (Department of Internal Medicine).

 

 

 

  1. Quantitative Trait Locus (QTL) Identification in Isolate Populations
  2. Quantitative Trait Locus (QTL) Identification in Isolate Populations Publications (this page)

 

 

Key Publications

Genetics of Isolated Populations

  1. Vitart, V.; Biloglav, Z.; Hayward, C.; Janicijevic, B.; Smolej-Narancic, N.; Barac, L.; Pericic, M.; Klaric, I.M.; Skaric-Juric, T.; Barbalic, M.; Polasek, O.; Kolcic, I.; Carothers, A.; Rudan, P.; Hastie, N.; Wright, A.; Campbell, H. and Rudan, I. 3000 years of solitude: extreme differentiation in the island isolates of Dalmatia, Croatia.
    Eur J Hum Genet 14(4):478-487, 2006 PubMed Abstract
  2. Vitart, V.; Carothers, A.D.; Hayward, C.; Teague, P.; Hastie, N.D.; Campbell, H. and Wright, A.F. Increased level of linkage disequilibrium in rural compared with urban communities: a factor to consider in association-study design.
    Am J Hum Genet 76(5):763-772, 2005 PubMed Abstract
  3. Wright, A.F.; Carothers, A.D. and Pirastu, M. Population choice in mapping genes for complex diseases.
    Nature Genetics     23(12):397-404, 1999 
    PubMed Abstract

Genetic Architecture of Complex Traits

  1. Aulchenko, Y.S.; Ripatti, S.; Lindqvist, I.; Boomsma, D.; Heid, I.M.; Pramstaller, P.P.; Penninx, B.W.; Janssens, A.C.; Wilson, J.F.; Spector, T.; Martin, N.G.; Pedersen, N.L.; Kyvik, K.O.; Kaprio, J.; Hofman, A.; Freimer, N.B.; Jarvelin, M.R.; Gyllensten, U.; Campbell, H.; Rudan, I.; Johansson, A.; Marroni, F.; Hayward, C.; Vitart, V.; Jonasson, I.; Pattaro, C.; Wright, A.; Hastie, N.; Pichler, I.; Hicks, A.A.; Falchi, M.; Willemsen, G.; Hottenga, J.J.; de Geus, E.J.; Montgomery, G.W.; Whitfield, J.; Magnusson, P.; Saharinen, J.; Perola, M.; Silander, K.; Isaacs, A.; Sijbrands, E.J.; Uitterlinden, A.G.; Witteman, J.C.; Oostra, B.A.; Elliott, P.; Ruokonen, A.; Sabatti, C.; Gieger, C.; Meitinger, T.; Kronenberg, F.; Doring, A.; Wichmann, H.E.; Smit, J.H.; McCarthy, M.I.; van Duijn, C.M. and Peltonen, L. Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.
    Nat Genet 41(1):47-55, 2009
    PubMed Abstract
  2. Johansson, A.; Marroni, F.; Hayward, C.; Franklin, C.S.; Kirichenko, A.V.; Jonasson, I.; Hicks, A.A.; Vitart, V.; Isaacs, A.; Axenovich, T.; Campbell, S.; Dunlop, M.G.; Floyd, J.; Hastie, N.; Hofman, A.; Knott, S.; Kolcic, I.; Pichler, I.; Polasek, O.; Rivadeneira, F.; Tenesa, A.; Uitterlinden, A.G.; Wild, S.H.; Zorkoltseva, I.V.; Meitinger, T.; Wilson, J.F.; Rudan, I.; Campbell, H.; Pattaro, C.; Pramstaller, P.; Oostra, B.A.; Wright, A.F.; van Duijn, C.M.; Aulchenko, Y.S. and Gyllensten, U. Common variants in the JAZF1 gene associated with height identified by linkage and genome-wide association analysis. Hum Mol Genet 18(2):373-380, 2009 PubMed Abstract
  3. McQuillan, R.; Leutenegger, A.L.; Abdel-Rahman, R.; Franklin, C.S.; Pericic, M.; Barac-Lauc, L.; Smolej-Narancic, N.; Janicijevic, B.; Polasek, O.; Tenesa, A.; Macleod, A.K.; Farrington, S.M.; Rudan, P.; Hayward, C.; Vitart, V.; Rudan, I.; Wild, S.H.; Dunlop, M.G.; Wright, A.F.; Campbell, H. and Wilson, J.F. Runs of homozygosity in European populations.
    Am J Hum Genet 83(3):359-372, 2008 PubMed Abstract
  4. Rudan, I.; Carothers, A.D.; Polasek, O.; Hayward, C.; Vitart, V.; Biloglav, Z.; Kolcic, I.; Zgaga, L.; Ivankovic, D.; Vorko-Jovic, A.; Wilson, J.F.; Weber, J.L.; Hastie, N.; Wright, A. and Campbell, H. Quantifying the increase in average human heterozygosity due to urbanisation.
    Eur J Hum Genet 16(9):1097-102, 2008 PubMed Abstract
  5. Vitart, V.; Rudan, I.; Hayward, C.; Gray, N.K.; Floyd, J.; Palmer, C.N.; Knott, S.A.; Kolcic, I.; Polasek, O.; Graessler, J.; Wilson, J.F.; Marinaki, A.; Riches, P.L.; Shu, X.; Janicijevic, B.; Smolej-Narancic, N.; Gorgoni, B.; Morgan, J.; Campbell, S.; Biloglav, Z.; Barac-Lauc, L.; Pericic, M.; Klaric, I.M.; Zgaga, L.; Skaric-Juric, T.; Wild, S.H.; Richardson, W.A.; Hohenstein, P.; Kimber, C.H.; Tenesa, A.; Donnelly, L.A.; Fairbanks, L.D.; Aringer, M.; McKeigue, P.M.; Ralston, S.H.; Morris, A.D.; Rudan, P.; Hastie, N.D.; Campbell, H. and Wright, A.F. SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout. Nat Genet 40(4):437-442, 2008 PubMed Abstract