Dr Andrew Jackson: Medical and Developmental Genetics
Genetic disorders of growth, inflammation and the brain
Summary
To gain new biological insights and a better understanding of human disease pathogenesis, our starting point is the identification of genes for inherited neurological disorders. Through study of these genes function we aim to further define their biological roles and understand the disease mechanisms of common, complex trait, neurological and immunological disorders.
Current Funding
- MRC Senior Clinical Fellowship
- MRC Human Genetics Unit
- MRCT Development Gap Fund
- Lister Institute Prize Fellowship
Lab Members
Current lab members involved in this work are:
- Dr Louise Bicknell
Postdoctoral researcher - Dr Martin Reijns
Postdoctoral researcher - Dr Carol-Anne Martin
Postdoctoral researcher - Dr Rachel Rigby
Postdoctoral researcher - Dr Anna Klingseisen
Postdoctoral researcher - Dr Maggie Harley
Postdoctoral researcher - Dr Jennie Murray
Clinical Research Fellow - Dr David Hunt
Clinical Lecturer in Neurology - Andrea Leitch
Senior research technician - Ailsa Revuelta
Research Technician - Katy Astell
PhD student - Fay Cooper
PhD student (joint with Professor Robert Hill) - Sarah Cox
PhD student (joint with Dr Julia Dorin)
Themes
- Growth and human brain size
Primary Microcephaly
Primordial Dwarfism
- Neuro-inflammation: genetic mimics of viral infection
Aicardi Goutieres Syndrome
Other Links
Purpose
The overall aim of this programme is to gain mechanistic biological insights from the identification of human disease genes, and the study of the proteins they encode in cells and in model organisms.
Collaborations
Growth and brain size
- Dr Mike Bober (Delaware), Dr Carol Wise (Dallas)
- Dr Ernie Bongers (Meier Gorlin syndrome)
Nijmegen, the Netherlands - Professor Bernd Wollnik (Cologne)
- Professor Valerie Cormier-Daire (Paris)
- Dr Paola Vagnerelli and Professor Bill Earnshaw
ICMB, Edinburgh - Dr Matt Hurles, Wellcome Trust Sanger Institute
- Dr Rob Semple, Cambridge
- Professor Siddharthan Chandran, Edinburgh.
- Dr Alexander von Kriegsheim, Dublin
- Walking with Giants Foundation (UK)
- Potentials Foundation (USA)
- Dr Julia Dorin/ Professor Bob Hill (HGU)
- Dr Martin Taylor (HGU)
AGS
- Professor Steve Anderton and Dr Andrew MacDonald
Institute of Immunology and Infection Research, Edinburgh - Dr Doryen Bubeck and Professor Yvonne Jones
Division of Structural Biology, Oxford - George Kassiotis, NIMR, London
- Dr David Brownstein
University of Edinburgh - Dr Min Ae Lee Kirsch, Dresden
- Professor Yanick Crow, Manchester
- Dr Kirsty Lawson (HGU)