Saturday 9 July 2011
13:00-14:00 Registration & Lunch (MRC Human Genetics Unit)
14:00 -14:15 Welcome by the Organizers
Session 1
Solid Tumors
Chair: Marina Mione
14.15 -14:30
The BMP Pathway is required for Differentiation in Zebrafish Germ Cells and Human Germ Cell Tumors
James F. Amatruda, University of Texas Southwestern
14:30 -14:45
UHRF1 is an Epigenetic Modifier and Oncogene in Liver Cancer
Kirsten C. Sadler, Mount Sinai School of Medicine
14:45 -15:00
Inducible and Repressible Oncogene-Addicted Hepatocellular Carcinoma in Tet-on and Mifepristone-Inducible Transgenic Zebrafish
Zhiyuan Gong, National University of Singapore
15:00-15:15
Oncogenic HRAS Induces Ago2 Over Expression Leading to an Aberrant miRNA Profile at the Early Stage of Transformation
Viviana Anelli, Foundazione Ifom
Featured Speaker
15:15 -15:45 The transposon-mediated Gal4-UAS method in zebrafish and calcium imaging with an improved GCaMP
Koichi Kawakami, National Institute of Genetics, Japan
15:45 - 16:15
Tea / Coffee / Exhibition / Poster Viewing (Common Room, MRC)
16:15 -16:30
Dynamic Nuclear Localization is required for PTEN Function in Development
Jeroen Den Hertog, Hubrecht Institute
16:30 -16:45
Melanoma suppression by Cdkn2
Manfred Schartl, University of Wuerzburg
16:45 -17:00
A Conditional Mutation Implicates Mitfa in Melanoma Development and Maintenance
James A. Lister, Virginia Commonweath University
17:00-17:15
Differentiated Cell Division in Melanocytes in vivo
Liz Patton, MRC Human Genetics Unit
17:15 -17:30
Break (Common Room, MRC)
Keynote Speaker
17:30-18:30
Cancer, Development and Adult Tissue Maintenance
Nick Hastie, MRC Human Genetics Unit, Edinburgh
18:30-20:00
Cheese and Wine Reception – Poster Viewing Session 1
Common Room, MRC Human Genetics Unit
Sunday 10 July 2011
Session 2
Cancer genetics and biology
Chair: Jim Amatruda
08:45 -09:00
Whole Exome Sequencing of BRAF and NRAS Models of Zebrafish Melanoma
Jennifer Yen, Wellcome Trust Sanger Institute
09:00-09:15
The Role of Pten in Zebrafish during Development and Tumor Progression
Suma Choorapoikayil, Hubrecht Institute
09:15 -09:30
H2O2 as a modulator of tumor angiogenesis
Carla Real, Faculdade De Ciências Da Universidade De Lisboa
09:30 -09:45
Telomere and Telomerase Behavior in Cancer, Aging and Regeneration
Monique Anchelin, Fundacion Para La Formación E Investigación De La Región De Murcia
09:45 -10:00
Shared Acquired Genomic Changes in Danio rerio and Human T-ALL
Kimble Frazer, University of Utah
10:00 -10:15
NUP98-HOXA9 Drives High-Risk Myeloid Leukemia in Zebrafish - A Platform to Study b-catenin and Perform Drug Discovery
Michael Forrester, Dalhousie University
10:15-10:45 Tea / Coffee / Exhibition / Poster Viewing
Session 3
Novel Therapeutics in Cancer and Infection
Chair: Nick Trede
10:45 -11:00
A Novel Mechanism of Action for Kalihinol F Elucidated from a Zebrafish-Based Phenotypic Screen
Imelda Sandoval, The University of Utah
11:00 -11:15
Identification of Novel Wnt Signaling Inhibitors Using a Synthetic Lethality Screen in Zebrafish
David Jones, Huntsman Cancer Institute
11:15 -11:30
The Zebrafish as a Model System for Glucocorticoid Resistance
Marcel Schaaf, Leiden University
11:30 -11:45
Leukemia and Breast Cancer Xenotransplantation in Zebrafish Chemotherapy Response Assay in Vivo
Graham Dellaire, Dalhousie University
11:45 -12:00
Pre-Clinical Therapeutic Trials Using Zebrafish with T Cell Malignancy
Kimble Frazer, University of Utah
12:00-12:15
Zebrafish Platform for Screening Novel Tuberculosis Vaccine Antigens
Kaisa Oksanen, University Of Tampere
12:15 -12:30
The Zebrafish Embryo Early Granuloma Infection Model:
A Promising Tool for Antitubercular Compound Screens in Vivo
Astrid Van Der Sar, VU University Medical Center
12:30-14:30 Lunch / Exhibition / Poster Viewing
Session 4
Immune Response to Infection
Chair: Lalli Ramakrishnan
Featured Speaker
14:30 -15:00
Genotype-directed therapeutics for tuberculosis that balance the effect of host inflammatory mediators
David Tobin, Duke University Medical Center, UK
15:00 -15:15
Zebrafish Embryo Screen to Identify Mycobacterial Genes Involved in Granuloma
Esther Stoop, VU University Medical Center
15:15 -15:30
Individual Cell Tracking in a Transgenic ZebrafishInflammation Model Reveals the Fates of Inflammatory Neutrophils During Inflammation Resolution
Stephen Renshaw, University of Sheffield
15:30 15:45
lnterplay Between Neutrophils and Macrophages During Tumour Growth and Response to Treatment: Use of a Novel Zebrafish Model
Steven Churchill, University Of Sheffield
15:45 -16:15 Refreshment Break
16:15 -16:30
Microbial Presence Primes Innate Immunity and Increases Disease Resistance of Zebrafish Larvae
Victor Mulero, Universidad De Murcia
16:30 -16:45
Leukocyte-Derived Myeloperoxidase Dampens Wound-Induced Hydrogen Peroxide
Graham Lieschke, Australian Regenerative Medicine Institute
16:45 -17:00
Using zebrafish embryos to understand staphylococcal disease
Tomek Prajsnar, University of Sheffield
17:00-18:15 Tea / Coffee / Exhibition / Poster Viewing Session 2
19:30 -00:00
ZDM4 Dinner for everyone! The Caves, 8-12 Niddry Street South, Edinburgh EH1 1NS
Monday 11 July 2011
Session 5
Hematopoiesis
Chair: Len Zon
Featured Speaker
09:00- 09:30
Control of Hematopoietic Stem Cell Production
Len Zon, HHMI/Children's Hospital Boston
09:30 -09:45
Clonal Analysis of Zebrafish Hematopoietic Stem and Progenitor Cells
David L Stachura, University of California, San Diego
09:45 -10:00
Unraveling the Genetic Logic Underpinning Cell Fate Decisions of Blood Stem Cells in Zebrafish Embryos
Rui Monteiro, Weatherall Institute of Molecular Medicine
10:00 -10:15
Deficiency of the Zebrafish Homologue of the Murine Ecotropic Viral Integration Site-1 (evi-1) Gene Strongly Impairs Embryonic Myelopoiesis as well as HSC Development and can be rescued by gata2
Martina Konantz, University of Tuebingen Medical Center
10:15 -10:30
LIM-Only Domain (LMO) Proteins in Developmental Haematopoiesis
Kapil Tuladhar, Weatherall Institute of Molecular Medicine
10:30 -10:45
Metabolism-Induced Reactive Oxygen Species (ROS) and hif1a Stimulation control the Induction and Expansion of Hematopoietic Stem Cells
Trista North, Harvard Medical School
10:45 -11:00
The Blood System Under Stress: Understanding the Haematopoietic Response to Infection
Chris Hall, The University of Auckland
11:00-11:45 Tea / Coffee
Session 6
Innate Immunity and Disease
Chair: Herman Spaink
Featured Speaker
11.45 -12.00
Cellular and Genetic Dissection of the Role of Neutrophils in Tuberculosis
Lalli Ramakrishnan, University of Washington
12.00 -12:15
Myeloid-Specific Gene Functions in the Innate Immune Response to Intracellular Bacterial Pathogens
Annemarie H Meijer, Leiden University
12:15 -12:30
Live Imaging in a Zebrafish Cancer Model Reveals a Key Contribution by Inflammation
Yi Feng, University of Bristol
12:30 -12:45
VEGFR targeting elicits metastasis by modification of myeloid cells in a zebrafish xenograft model
Shuning He, Leiden University
12:45 -13.00
Transgenic Zebrafish Expressing the D816V CKIT Mutation Demonstrate
Features of Human Systemic Mastocytosis
Tugce Balci, Dalhousie University
13.00 -13:15
An Early Developmental Role for a Zebrafish β-Defensin-like Peptide
Julia Dorin, MRC Human Genetics Unit
13:15 -14:15 Lunch
14:15 -14:30
Altered Intestinal Microbial Composition and Innate Immunity in Rag1-/- Zebrafish
Sylvia Burgman, Department of Pediatric immunology, Wilhelmina Children’s Hospital Utrecht
14:30 -14:45
A potent antiviral response elicited in zebrafish larvae by a human arbovirus
Jean-Pierre Levraud, Institut Pasteur
Session 7
Development and Disease
Chair: Keith Cheng
14.45 -15.00
Induction of Autophagy in a Zebrafish Ribosomal RNA Processing Mutant
Joan K Heath, Ludwig Institute for Cancer Research, Australia
15.00 -15.15
A Zebrafish Model of Dyskeratosis Congenita Reveals Haematopoetic Stem Cell formation failure due to Ribosomal Protein-Mediated p53 Stabilization
Alyson MacInnes, Hubrecht Institute
15.15 -15.30
Estrogen Exhibits a Biphasic Role on Liver Development Mediated by Esr2 and Affects Liver Regeneration
Wolfram Goessling, Harvard Medical School
15.30 -15.45
Nitric Oxide Signaling Regulates Liver Development and Regeneration Via Two Independent Mechanisms
Andrew Cox, Harvard Medical School
15.45 -16.00
Protein Kinase D2 Regulates Cardiac Valve Development
Dimitris Beis, Biomedical Research Foundation Academy of Athens
16:00 -16.15
Computational phenomics
Keith Cheng, Penn State College of Medicine
16.15 -16.30 Prizes and Concluding Remarks
19:15-20.15
Organ Concert by Graham Lieschke at St Giles’ Cathedral, Royal Mile
with Len Zon and Wolfram Goessling (trumpets)
19:30
Farewell Drinks at The Beehive Inn (18-20 Grassmarket EH1 2EL)
